2C-B (2,5-dimethoxy-4-bromophenethylamine) is a psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin in 1974. In Shulgin’s book PiHKAL, the dosage range is listed as 12–24 mg. As a recreational drug, 2C-B is sold as a white or pale pink powder sometimes pressed in tablets or gel caps. It is also referred to by a number of street names, including cocaína rosada for its rosy color. The drug is usually taken orally, but can also be snorted (insufflated) or vaporized.
Little or no academic research has been conducted on the effects of 2C-B in humans. The information available is largely anecdotal and limited. Effects are often described as being more easily managed than other psychedelics; it is often compared to a mixture of a serotonergic psychedelic and MDMA. At 5–10 mg, experiments with young chickens have shown it to produce effects similar to a low dosage of amphetamines.
The anecdotal effects of 2C-B that have been reported by users on online discussion forums include:
- At low doses the experience may shift in intensity from engaging to mild/undetectable. Experienced users report the ability to take control of the effects and switch from engaged to sober at will
- The hallucinations have a tendency to decrease and then increase in intensity, giving the users a sense of “waves” or even glowing. These are popularly described as “clichéd ’70s visuals” or objects taking on “water color” like textures
- While the effects of the drug often render users unable to concentrate deeply on anything in particular, some can become engrossed in an activity such as watching a movie or playing a video game, distracting themselves from the visual and auditory effects of the drug
- Excessive giggling or smiling is common, as is a tendency for deeper “belly laughs”
- Some users say that the effects are more intense when listening to music and report that they can see sounds and noises
- Some users experience a decrease in visual acuity, although others report sharper vision
- Increased awareness of one’s body; attention may be brought to perceived “imperfections” or internal body processes.
The following effects are highly dose-dependent.
- Open eye visuals (OEVs), such as cartoon-like distortions and red or green halos around objects. Closed eye visuals (CEVs) are more common than OEVs.
- Affects and alters ability to communicate, engage in deep thought, or maintain attention span.
- Some users report experiencing frightening or fearful effects during the experience. Users describe feeling frigid or cold on reaching a plateau, while others feel wrapped in comfortable blankets/ultimate pleasure.
- Coordination may be affected, some users lose balance or have perceptual distinction problems.
- Onset time of 2C-B is highly dose dependent, but usually from 45 to 75 minutes. Taken on a full stomach, the onset time is increased to two hours or more.
- Before it was scheduled, 2C-B was sold in small doses as an aphrodisiac (see History). Some users report aphrodisiac effects at lower doses.
- Some users report mild “jitters” (body tremors), shuddering breath, and/or mild muscle spasms after insufflating 2C-B. Whether or not these effects are enjoyable depends on the user
- Mild to intense diarrhea, gas, nausea, and general gastrointestinal discomfort
- Severe headaches after coming down from large doses have been reported. However, many users report a lack of “comedown” or “crash”, instead noting a gradual return to sobriety
- At doses over 30–40 mg the user may experience frightening hallucinations, as well as tachycardia, hypertension, and hyperthermia
- 2C-B HCl is very painful to insufflate. Anecdotal evidence suggests that 2C-B HBr, the hydrobromide salt with greater water solubility, is less irritating to the mucous membranes lining the nose but slightly less potent when compared dose-for-dose with the HCl salt.
- Rectal administration of a water-based solution of 2C-B is known to be less painful than insufflation and much more potent than oral administration.
When orally consumed, 2C-B has a much longer delay before the onset of effects than when it is insufflated. Oral ingestion generally takes roughly 45–75 minutes for the effects to be felt, plateau lasts 2–4 hours, and coming down lasts 1–2 hours. Rectal administration onset varies from 5–20 minutes. Insufflated onset takes 1–10 minutes for effects to be felt. The duration can last from 4 to 12 hours depending on route of administration, dose, and other factors.
With insufflation, the effects are more abrupt and intense but have a significantly shorter duration, while oral usage results in a milder, longer experience. When insufflated, the onset happens very rapidly, usually reaching the peak at about 20–40 minutes and plateauing for 2–3 hours. 2C-B is also considered one of the most painful drugs to insufflate, with users reporting intense nasal burning.The sudden intensity of the experience combined with the pain can often start the experience with a negative imprint and nausea is also increased with insufflation, compounding the issue.